BAIT
SERPINB5
PI5, maspin
serpin peptidase inhibitor, clade B (ovalbumin), member 5
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GSTO1
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, RP11-99N20.1
glutathione S-transferase omega 1
GO Process (11)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [IDA]
- cellular response to arsenic-containing substance [IDA]
- glutathione derivative biosynthetic process [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IC]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- small molecule metabolic process [TAS]
- xenobiotic catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase.
Maspin, a novel serine protease inhibitor, suppresses tumor progression in several cancer models, including an in vivo model for prostate cancer bone metastasis. However, the molecular mechanism of maspin remains illusive, primarily because its molecular targets are unknown. To this end, we used a full-length maspin cDNA bait to screen against both a primary prostate tumor cDNA prey library and ... [more]
J. Biol. Chem. Oct. 14, 2005; 280(41);34985-96 [Pubmed: 16049007]
Throughput
- High Throughput
Curated By
- BioGRID