BAIT
SERPINB5
PI5, maspin
serpin peptidase inhibitor, clade B (ovalbumin), member 5
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATIC
AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, OK/SW-cl.86
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
GO Process (5)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase.
Maspin, a novel serine protease inhibitor, suppresses tumor progression in several cancer models, including an in vivo model for prostate cancer bone metastasis. However, the molecular mechanism of maspin remains illusive, primarily because its molecular targets are unknown. To this end, we used a full-length maspin cDNA bait to screen against both a primary prostate tumor cDNA prey library and ... [more]
J. Biol. Chem. Oct. 14, 2005; 280(41);34985-96 [Pubmed: 16049007]
Throughput
- High Throughput
Curated By
- BioGRID