BAIT
UBQLN2
Chap1, Dsk2, HRIHFB2157, Plic-2, Plic2, RP23-240F13.1
ubiquilin 2
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA2
70kDa, HSP70.2, HSP70A2, Hsp70-2
heat shock protein 2
GO Process (8)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- male meiosis [IMP]
- male meiosis I [IMP]
- negative regulation of inclusion body assembly [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of protein phosphorylation [IMP]
- protein refolding [ISO]
- spermatid development [IMP]
- synaptonemal complex disassembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Clearance of misfolded and aggregated proteins is central to cell survival. Here, we describe a new pathway for maintaining protein homeostasis mediated by the proteasome shuttle factor UBQLN2. The 26S proteasome degrades polyubiquitylated substrates by recognizing them through stoichiometrically bound ubiquitin receptors, but substrates are also delivered by reversibly bound shuttles. We aimed to determine why these parallel delivery mechanisms ... [more]
Cell Aug. 11, 2016; 166(4);935-949 [Pubmed: 27477512]
Throughput
- High Throughput
Curated By
- BioGRID