BAIT
FBXL13
Fbl13
F-box and leucine-rich repeat protein 13
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
RAPGEF4
2, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496
Rap guanine nucleotide exchange factor (GEF) 4
GO Process (8)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- blood coagulation [TAS]
- energy reserve metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of Ras GTPase activity [ISS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
Aberrant centrosome organisation with ensuing alterations of microtubule nucleation capacity enables tumour cells to proliferate and invade despite increased genomic instability. CEP192 is a key factor in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation. However, regulatory means of CEP192 have remained unknown. Here, we report that FBXL13, a binding determinant of SCF (SKP1-CUL1-F-box)-family ... [more]
EMBO Rep. Mar. 01, 2018; 19(3); [Pubmed: 29348145]
Throughput
- High Throughput
Additional Notes
- Fbxl13 isoform 1
- Purification from HEK293T using Flag tagged Fbxl13.
Curated By
- BioGRID