AQP2
Gene Ontology Biological Process
- actin filament depolymerization [ISO]
- apoptotic process [ISO]
- carbohydrate transmembrane transport [IBA]
- cell volume homeostasis [ISO]
- cellular response to copper ion [ISO]
- cellular response to mercury ion [ISO]
- cellular response to water deprivation [IDA, ISO]
- cellular water homeostasis [IBA]
- glycerol transport [IBA, ISO]
- ion transmembrane transport [IBA]
- positive regulation of calcium ion transport [ISO]
- renal water transport [IMP]
- transmembrane transport [IDA]
- water transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- clathrin-coated vesicle [ISO]
- cytoplasm [ISO]
- cytoplasmic vesicle [IDA]
- early endosome [ISO]
- exocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- integral component of endosome membrane [IC]
- integral component of membrane [ISM]
- integral component of plasma membrane [IBA, IC]
- lysosome [ISO]
- membrane [IDA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- recycling endosome [IDA]
- recycling endosome membrane [IC]
- rough endoplasmic reticulum [ISO]
- trans-Golgi network [ISO]
- transport vesicle [ISO]
STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70.
AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation and degradation, however the proteins involved in these processes are largely unknown. Here, we investigated the potential role of the CHIP E3 ligase in AQP2 regulation.MCD4 cells and kidney slices were used to study the involvement of the E3 ligase CHIP ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID