ITGB3
Gene Ontology Biological Process
- activation of protein kinase activity [IMP]
- angiogenesis involved in wound healing [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP]
- cell-substrate adhesion [IMP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [IDA, TAS]
- leukocyte migration [TAS]
- mesodermal cell differentiation [IEP]
- negative chemotaxis [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- platelet activation [IMP, TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein folding [IDA]
- regulation of bone resorption [TAS]
- smooth muscle cell migration [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- tube development [TAS]
- viral entry into host cell [IMP]
- wound healing [IC]
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
Gene Ontology Cellular Component
- alphav-beta3 integrin-vitronectin complex [TAS]
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [TAS]
- integrin alphav-beta3 complex [IDA]
- integrin complex [IDA]
- lamellipodium membrane [IDA]
- melanosome [IDA]
- microvillus membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- platelet alpha granule membrane [TAS]
- receptor complex [IDA]
- ruffle membrane [IDA]
CIB1
Gene Ontology Biological Process
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to growth factor stimulus [ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IMP]
- cytoplasmic microtubule organization [IMP]
- double-strand break repair [TAS]
- endomitotic cell cycle [IDA]
- extrinsic apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of megakaryocyte differentiation [ISS]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein phosphorylation [ISS]
- platelet formation [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell growth [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IGI]
- positive regulation of male germ cell proliferation [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of cell division [IMP]
- regulation of cell proliferation [IMP]
- response to ischemia [ISS]
- spermatid development [ISS]
- thrombopoietin-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell periphery [IDA]
- centrosome [IDA]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IMP]
- extracellular vesicular exosome [IDA]
- filopodium tip [IDA]
- growth cone [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA, IMP]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- sarcolemma [IDA]
- vesicle [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Calcium Integrin Binding Protein Associates with Integrins αVβ3and αIIbβ3Independent of β3Activation Motifs.
The Calcium Integrin Binding protein (CIB) has been identified as interacting specifically with the cytoplasmic tail of the integrin αIIbdomain to induce receptor activation and integrin αIIbβ3mediated cell adhesion to extracellular proteins. In K562 cells stably expressing mutated integrin αVβ3, or chimeric αVβ3carrying αIIbcytoplasmic tail, we report that the interaction of CIB with β3integrins is not αIIbβ3specific but binds αIIbas ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CIB1 ITGB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID