NCB2
Gene Ontology Biological Process
- RNA polymerase II transcriptional preinitiation complex assembly [IMP]
- negative regulation of tRNA transcription from RNA polymerase III promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
- regulation of RNA polymerase II transcriptional preinitiation complex assembly [IMP]
Gene Ontology Molecular Function- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
- TBP-class protein binding RNA polymerase II transcription factor activity [IDA, IPI]
- TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly [IMP]
- chromatin binding [IDA]
- core promoter binding [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [IDA, IGI, IMP]
Gene Ontology Cellular Component
RPO21
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Specific defects in different transcription complexes compensate for the requirement of the negative cofactor 2 repressor in Saccharomyces cerevisiae.
Negative cofactor 2 (NC2) has been described as an essential and evolutionarily conserved transcriptional repressor, although in vitro and in vivo experiments suggest that it can function as both a positive and a negative effector of transcription. NC2 operates by interacting with the core promoter and components of the basal transcription machinery, like the TATA-binding protein (TBP). In this work, ... [more]
Throughput
- Low Throughput
Ontology Terms
- viability (APO:0000111)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCB2 RPO21 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2451 | BioGRID | 1927758 |
Curated By
- BioGRID