FKH1
Gene Ontology Biological Process
- cellular response to methylmercury [IGI, IMP]
- chromatin remodeling [IGI, IMP]
- donor selection [IGI, IMP]
- mRNA 3'-end processing [IMP]
- mitochondrion organization [IBA]
- negative regulation of pseudohyphal growth [IGI]
- negative regulation of transcription elongation from RNA polymerase II promoter [IGI, IMP]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription involved in G2/M transition of mitotic cell cycle [IMP]
- positive regulation of DNA-dependent DNA replication initiation [IMP]
- positive regulation of chromatin silencing at silent mating-type cassette [IGI, IMP]
- positive regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- regulation of sequence-specific DNA binding transcription factor activity [IBA]
- termination of RNA polymerase II transcription [IGI, IMP]
Gene Ontology Molecular Function- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- centromeric DNA binding [IDA]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IGI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- centromeric DNA binding [IDA]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
Gene Ontology Cellular Component
FKH2
Gene Ontology Biological Process
- chromatin remodeling [IGI, IMP]
- mitochondrion organization [IBA]
- negative regulation of chromatin silencing at silent mating-type cassette [IGI, IMP]
- negative regulation of pseudohyphal growth [IGI, IMP]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- positive regulation of DNA-dependent DNA replication initiation [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI, IMP]
- regulation of sequence-specific DNA binding transcription factor activity [IBA]
Gene Ontology Molecular Function- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II transcription factor binding [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, IGI, IMP]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
- DNA replication origin binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II transcription factor binding [IDA, IMP]
- RNA polymerase II transcription factor binding transcription factor activity [IDA, IGI, IMP]
- double-stranded DNA binding [IBA]
- sequence-specific DNA binding [IDA]
- transcription factor binding [IBA]
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Rapid Nuclear Exclusion of Hcm1 in AgingSaccharomyces cerevisiaeLeads to Vacuolar Alkalization and Replicative Senescence.
The yeast,Saccharomyces cerevisiae, like other higher eukaryotes, undergo a finite number of cell divisions before exiting the cell cycle due to the effects of aging. Here, we show that yeast aging begins with the nuclear exclusion of Hcm1 in young cells, resulting in loss of acidic vacuoles. Autophagy is required for healthy aging in yeast, with proteins targeted for turnover ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vacuolar morphology (APO:0000059)
Additional Notes
- Deleting both FKH1 and FKH2, however, led to loss of vacuolar acidity
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FKH2 FKH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -4.8888 | BioGRID | 542416 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2394138 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156232 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 239904 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1537658 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2334836 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 644770 | |
| FKH2 FKH1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2198006 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 256839 | |
| FKH1 FKH2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 156230 | |
| FKH1 FKH2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| FKH1 FKH2 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 3455074 | |
| FKH1 FKH2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 158049 |
Curated By
- BioGRID