BAIT

BAALC

brain and acute leukemia, cytoplasmic
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens
PREY

RNF2

BAP-1, BAP1, DING, HIPI3, RING1B, RING2, GS1-120K12.1
ring finger protein 2
UPS Project
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.

Morita K, Masamoto Y, Kataoka K, Koya J, Kagoya Y, Yashiroda H, Sato T, Murata S, Kurokawa M

Although high brain and acute leukemia, cytoplasmic (BAALC) expression is a well-characterized poor prognostic factor in acute myeloid leukemia (AML), neither the exact mechanisms by which BAALC drives leukemogenesis and drug resistance nor therapeutic approaches against BAALC-high AML have been properly elucidated. In this study, we found that BAALC induced cell-cycle progression of leukemia cells by sustaining extracellular signal-regulated kinase ... [more]

Leukemia Nov. 01, 2015; 29(11);2248-56 [Pubmed: 26050649]

Throughput

  • Low Throughput

Curated By

  • BioGRID