TAPBP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TAP1
Gene Ontology Biological Process
- ATP catabolic process [IBA, ISO]
- antigen processing and presentation of endogenous peptide antigen via MHC class I [ISO]
- cytosol to ER transport [ISO]
- defense response [IMP]
- intracellular transport of viral protein in host cell [ISO]
- peptide transport [ISO]
- protection from natural killer cell mediated cytotoxicity [ISO]
- transmembrane transport [IBA]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class I protein binding [IPI, ISO]
- MHC class Ib protein binding [ISO]
- TAP1 binding [ISO]
- TAP2 binding [ISO]
- nucleotide binding [ISO]
- peptide antigen binding [ISO]
- peptide transporter activity [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- tapasin binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class I protein binding [IPI, ISO]
- MHC class Ib protein binding [ISO]
- TAP1 binding [ISO]
- TAP2 binding [ISO]
- nucleotide binding [ISO]
- peptide antigen binding [ISO]
- peptide transporter activity [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- tapasin binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of murine MHC class I molecules with tapasin and TAP enhances peptide loading and involves the heavy chain alpha3 domain.
In human cells the association of MHC class I molecules with TAP is thought to be mediated by a third protein termed tapasin. We now show that tapasin is present in murine TAP-class I complexes as well. Furthermore, we demonstrate that a mutant H-2Dd molecule that does not interact with TAP due to a Glu to Lys mutation at residue ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID