BAIT
FAM92A
6720467C03Rik, Fam92a1, RP24-215D6.5
family with sequence similarity 92, member A
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
PREY
TBX18
2810012F10Rik, 2810404D13Rik
T-box18
GO Process (17)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- anatomical structure formation involved in morphogenesis [IMP]
- anterior/posterior axis specification [IMP]
- cell differentiation [IMP]
- cochlea morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cell-cell adhesion [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mesenchymal cell proliferation involved in ureter development [IGI]
- sensory perception of sound [IMP]
- sinoatrial node development [IMP]
- smooth muscle cell differentiation [IMP]
- somitogenesis [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureter development [IGI]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription corepressor activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription corepressor activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.
Primary cilia organize Hedgehog signaling and shape embryonic development, and their dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hedgehog-responsive cells and applying genome-wide CRISPR-mediated gene disruption. The screen can robustly identify factors required for ciliary signaling with few false positives or false negatives. Characterization of hit ... [more]
Nat. Genet. Mar. 01, 2018; 50(3);460-471 [Pubmed: 29459677]
Throughput
- High Throughput
Curated By
- BioGRID