BAIT
TTC23
1600012K10Rik
tetratricopeptide repeat domain 23
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
SOX1
BB176347, Sox-1
SRY (sex determining region Y)-box 1
GO Process (8)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- forebrain development [IMP]
- forebrain neuron development [IMP]
- forebrain neuron differentiation [IMP]
- lens morphogenesis in camera-type eye [IMP]
- neuron migration [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- ventral spinal cord interneuron specification [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [ISO]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [ISO]
- sequence-specific DNA binding [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.
Primary cilia organize Hedgehog signaling and shape embryonic development, and their dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hedgehog-responsive cells and applying genome-wide CRISPR-mediated gene disruption. The screen can robustly identify factors required for ciliary signaling with few false positives or false negatives. Characterization of hit ... [more]
Nat. Genet. Mar. 01, 2018; 50(3);460-471 [Pubmed: 29459677]
Throughput
- High Throughput
Curated By
- BioGRID