EYA1
Gene Ontology Biological Process
- anatomical structure development [IGI]
- aorta morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IGI]
- cell fate commitment [IMP]
- cellular protein localization [IMP]
- cochlea morphogenesis [IMP]
- double-strand break repair [ISO]
- embryonic skeletal system morphogenesis [IMP]
- establishment of mitotic spindle orientation [IGI, IMP]
- establishment or maintenance of apical/basal cell polarity [IMP]
- histone dephosphorylation [ISO]
- inner ear morphogenesis [IGI, IMP]
- lung epithelial cell differentiation [IGI]
- mesodermal cell fate specification [IDA]
- metanephros development [IMP]
- middle ear morphogenesis [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- neuron fate specification [IGI]
- organ morphogenesis [IMP]
- otic vesicle development [IGI]
- otic vesicle morphogenesis [IMP]
- outer ear morphogenesis [IMP]
- outflow tract morphogenesis [IMP]
- pattern specification process [IGI, IMP]
- peptidyl-tyrosine dephosphorylation [IDA]
- pharyngeal system development [IMP]
- positive regulation of DNA repair [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of secondary heart field cardioblast proliferation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA]
- protein dephosphorylation [IDA]
- protein sumoylation [IDA]
- regulation of neuron differentiation [IGI, IMP]
- response to ionizing radiation [ISO]
- semicircular canal morphogenesis [IMP]
- striated muscle tissue development [IGI]
- ureteric bud development [IGI]
Gene Ontology Molecular Function
SIX5
Gene Ontology Biological Process
- lens development in camera-type eye [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of skeletal muscle satellite cell proliferation [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- spermatid development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.
Mutations in the EYA1 gene are responsible for branchio-oto-renal (BOR) syndrome as well as for other ocular defects. Most of the mutations are located within or in the vicinity of the EYA domain, which is highly conserved in the EYA protein family. The EYA domain is required for protein-protein interactions, which are important to the biological function of EYA proteins. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EYA1 SIX5 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID