A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

GAS2 and GAS4, a pair of developmentally regulated genes required for spore wall assembly in Saccharomyces cerevisiae.

Ragni E, Coluccio A, Rolli E, Rodriguez-Pena JM, Colasante G, Arroyo J, Neiman AM, Popolo L

The GAS multigene family of Saccharomyces cerevisiae is composed of five paralogs (GAS1 to GAS5). GAS1 is the only one of these genes that has been characterized to date. It encodes a glycosylphosphatidylinositol-anchored protein functioning as a beta(1,3)-glucan elongase and required for proper cell wall assembly during vegetative growth. In this study, we characterize the roles of the GAS2 and ... [more]

Eukaryotic Cell Feb. 01, 2007; 6(2);302-16 [Pubmed: 17189486]

Throughput

Low Throughput

Ontology Terms

phenotype: sporulation efficiency (APO:0000044)
phenotype: spore wall formation (APO:0000043)

Additional Notes

percentage of unsporulated cells

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
GAS2 GAS4	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Szappanos B (2011)	High	-0.1006	BioGRID	540457

Curated By

BioGRID

Interaction Summary

GAS2

Gene Ontology Biological Process

Gene Ontology Molecular Function

1,3-beta-glucanosyltransferase activity [IDA, ISS]

Gene Ontology Cellular Component

GAS4