BAIT
PPP1R12A
1200015F06Rik, 5730577I22Rik, AA792106, AV099298, D10Ertd625e, Mypt1
protein phosphatase 1, regulatory (inhibitor) subunit 12A
GO Process (8)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- centrosome organization [ISO]
- mitotic nuclear division [ISO]
- negative regulation of catalytic activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- regulation of cell adhesion [ISO]
- regulation of myosin-light-chain-phosphatase activity [ISO]
- regulation of nucleocytoplasmic transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PPP1CC
PP-1G, PP1, dis2m1
protein phosphatase 1, catalytic subunit, gamma isoform
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.
Phospho-telokin is a target of elevated cyclic nucleotide concentrations that lead to relaxation of gastrointestinal and some vascular smooth muscles (SM). Here, we demonstrate that in telokin-null SM, both Ca(2+)-activated contraction and Ca(2+) sensitization of force induced by a GST-MYPT1(654-880) fragment inhibiting myosin light chain phosphatase were antagonized by the addition of recombinant S13D telokin, without changing the inhibitory phosphorylation ... [more]
J. Biol. Chem. Jun. 15, 2012; 287(25);20975-85 [Pubmed: 22544752]
Throughput
- Low Throughput
Curated By
- BioGRID