PPP1R12A
Gene Ontology Biological Process
- centrosome organization [ISO]
- mitotic nuclear division [ISO]
- negative regulation of catalytic activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IMP, ISO]
- regulation of cell adhesion [ISO]
- regulation of myosin-light-chain-phosphatase activity [ISO]
- regulation of nucleocytoplasmic transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP1CC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.
Phospho-telokin is a target of elevated cyclic nucleotide concentrations that lead to relaxation of gastrointestinal and some vascular smooth muscles (SM). Here, we demonstrate that in telokin-null SM, both Ca(2+)-activated contraction and Ca(2+) sensitization of force induced by a GST-MYPT1(654-880) fragment inhibiting myosin light chain phosphatase were antagonized by the addition of recombinant S13D telokin, without changing the inhibitory phosphorylation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID