Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.

Khromov AS, Momotani K, Jin L, Artamonov MV, Shannon J, Eto M, Somlyo AV

Phospho-telokin is a target of elevated cyclic nucleotide concentrations that lead to relaxation of gastrointestinal and some vascular smooth muscles (SM). Here, we demonstrate that in telokin-null SM, both Ca(2+)-activated contraction and Ca(2+) sensitization of force induced by a GST-MYPT1(654-880) fragment inhibiting myosin light chain phosphatase were antagonized by the addition of recombinant S13D telokin, without changing the inhibitory phosphorylation ... [more]

J. Biol. Chem. Jun. 15, 2012; 287(25);20975-85 [Pubmed: 22544752]

Throughput

  • Low Throughput

Curated By

  • BioGRID