BAIT
RNF169
ring finger protein 169
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAPZA1
CAPPA1, CAPZ, CAZ1
capping protein (actin filament) muscle Z-line, alpha 1
GO Process (4)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual-utility NLS drives RNF169-dependent DNA damage responses.
Loading of p53-binding protein 1 (53BP1) and receptor-associated protein 80 (RAP80) at DNA double-strand breaks (DSBs) drives cell cycle checkpoint activation but is counterproductive to high-fidelity DNA repair. ring finger protein 169 (RNF169) maintains the balance by limiting the deposition of DNA damage mediator proteins at the damaged chromatin. We report here that this attribute is accomplished, in part, by ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 04, 2017; 114(14);E2872-E2881 [Pubmed: 28325877]
Throughput
- Low Throughput
Curated By
- BioGRID