FGF2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- activation of MAPK activity [TAS]
- branching involved in ureteric bud morphogenesis [IDA]
- cell migration involved in sprouting angiogenesis [IDA, IGI]
- chemotaxis [TAS]
- chondroblast differentiation [IDA]
- embryonic morphogenesis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- hyaluronan catabolic process [IDA]
- innate immune response [TAS]
- inositol phosphate biosynthetic process [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of wound healing [IDA]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- phosphatidylinositol biosynthetic process [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell fate specification [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of angiogenesis [TAS]
- release of sequestered calcium ion into cytosol [IDA]
- signal transduction [NAS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SDC4
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin.
Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble heparin-binding growth factors (e.g., fibroblast growth factor, Wnt, Hh, transforming growth factor beta, amphiregulin, and hepatocyte growth factor) to their respective signaling receptors. We demonstrate that the deglycanated core protein of syndecan-1 (SDC1) and not HS chains nor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SDC4 FGF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3066041 |
Curated By
- BioGRID