BAIT
PTK2
FAK, FRNK, Fadk, mKIAA4203, p125FAK
PTK2 protein tyrosine kinase 2
GO Process (50)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- angiogenesis [IMP]
- blood vessel development [IMP]
- cellular chloride ion homeostasis [ISO]
- cellular component movement [TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system neuron axonogenesis [IMP]
- endothelial cell migration [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [IDA]
- extracellular matrix organization [IMP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, TAS]
- microtubule cytoskeleton organization [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [IGI]
- negative regulation of synapse assembly [IMP]
- neuron migration [IDA, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- regulation of cell adhesion [IBA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cell proliferation [ISO]
- regulation of cell shape [ISO]
- regulation of osteoblast differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- lamellipodium [IDA]
- nuclear body [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
Mus musculus
PREY
GRIN1
GluN1, NMDAR1, NR1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
GO Process (55)
GO Function (17)
GO Component (18)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo.
Tyrosine kinase phosphorylation plays an important role in the induction of long-term potentiation (LTP). Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that shows decreased phosphorylation in fyn mutant mice, and Fyn plays a critical role in LTP induction. By examining the role of FAK involved in LTP induction in dentate gyrus in vivo with medial perforant ... [more]
J. Neurosci. May. 15, 2003; 23(10);4072-80 [Pubmed: 12764094]
Throughput
- Low Throughput
Curated By
- BioGRID