BAIT
BRAF
B-RAF1, BRAF1, NS7, RAFB1
B-Raf proto-oncogene, serine/threonine kinase
GO Process (12)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- activation of MAPKK activity [TAS]
- cellular response to calcium ion [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- negative regulation of apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNAJC15
DNAJD1, HSD18, MCJ, GIG22
DnaJ (Hsp40) homolog, subfamily C, member 15
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.
B-Raf represents a critical physiological regulator of the Ras/RAF/MEK/ERK-pathway and a pharmacological target of growing clinical relevance, in particular in oncology. To understand how B-Raf itself is regulated, we combined mass spectrometry with genetic approaches to map its interactome in MCF-10A cells as well as in B-Raf deficient murine embryonic fibroblasts (MEFs) and B-Raf/Raf-1 double deficient DT40 lymphoma cells complemented ... [more]
Oncotarget May. 03, 2016; 7(18);26628-52 [Pubmed: 27034005]
Throughput
- High Throughput
Curated By
- BioGRID