BAIT
FBXO4
FBX4
F-box protein 4
GO Process (6)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FXR1
1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p
fragile X mental retardation gene 1, autosomal homolog
GO Process (2)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.
The Fbxo4 tumour suppressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known. Here we show purification of SCFFbxo4 complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding partners. Biochemical and functional analyses reveal that Fxr1 is a direct substrate of SCFFbxo4. Consistent with a substrate relationship, Fxr1 ... [more]
Nat Commun Nov. 16, 2017; 8(1);1534 [Pubmed: 29142209]
Throughput
- High Throughput
Curated By
- BioGRID