BAIT
GIG
6975, C1, CG6975, Dmel\CG6975, Gigas, ME 109, TSC2, Tsc2/gig, dTSC2, l(3)109, Dmel_CG6975
gigas
GO Process (27)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- TORC1 signaling [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to hypoxia [IMP]
- determination of adult lifespan [IMP]
- insulin-like growth factor receptor signaling pathway [IBA]
- larval midgut histolysis [IGI]
- lateral inhibition [IMP]
- lipid metabolic process [IGI]
- negative regulation of TOR signaling [IBA]
- negative regulation of Wnt signaling pathway [IBA]
- negative regulation of cell growth [IGI, IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of cell size [IGI, IMP]
- negative regulation of insulin receptor signaling pathway [IGI]
- negative regulation of organ growth [IGI]
- negative regulation of synaptic growth at neuromuscular junction [IMP]
- oogenesis [IMP]
- phagocytosis [IMP]
- positive regulation of GTPase activity [IBA]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of autophagy [IMP]
- positive regulation of protein phosphorylation [IDA]
- protein kinase B signaling [IBA]
- regulation of cell cycle [IMP]
- regulation of phosphorylation [IDA]
- response to nutrient [IMP]
- signal transduction [IGI]
Gene Ontology Molecular Function
Drosophila melanogaster
PREY
NAK
CG10637, Dmel\CG10637, Dmel_CG10637
Numb-associated kinase
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Drosophila melanogaster
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi.
The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate mTOR complex 1 (mTORC1). Mutation or aberrant inhibition of the TSC complex is common in various human tumor syndromes and cancers. The discovery of novel therapeutic strategies ... [more]
Sci Signal Sep. 08, 2015; 8(393);rs9 [Pubmed: 26350902]
Throughput
- Low Throughput
Additional Notes
- Tsc2 knock-out created with CRISPR
Curated By
- BioGRID