SHANK3
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- N-methyl-D-aspartate receptor clustering [ISO, ISS]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO, ISS]
- brain morphogenesis [ISO, ISS]
- dendritic spine morphogenesis [ISO, ISS]
- embryonic epithelial tube formation [ISO]
- guanylate kinase-associated protein clustering [ISO, ISS]
- learning [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- negative regulation of cell volume [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- positive regulation of dendritic spine development [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO, ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- positive regulation of synapse structural plasticity [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density assembly [ISO, ISS]
- protein oligomerization [IDA]
- regulation of behavioral fear response [ISO, ISS]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of long term synaptic depression [ISO, ISS]
- regulation of long-term synaptic potentiation [ISO, ISS]
- social behavior [ISO, ISS]
- striatal medium spiny neuron differentiation [ISO, ISS]
- synapse assembly [ISO, ISS]
- vocal learning [ISO]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAP1B
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- platelet activation [TAS]
- regulation of cell junction assembly [IMP]
- regulation of establishment of cell polarity [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.
SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN domain is an unexpected Ras-association domain with high affinity for GTP-bound Ras and Rap G-proteins. The role of Rap1 in integrin activation is well established but the ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of RAP1B not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHANK3 RAP1B | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 2397211 |
Curated By
- BioGRID