MST1
Gene Ontology Biological Process
Gene Ontology Cellular Component
TNNI3
Gene Ontology Biological Process
- cardiac muscle contraction [IDA, IMP, ISO]
- cellular calcium ion homeostasis [ISO]
- heart contraction [ISO]
- heart development [ISO]
- negative regulation of ATPase activity [ISO]
- regulation of muscle contraction [ISO, TAS]
- regulation of smooth muscle contraction [IMP]
- regulation of systemic arterial blood pressure by ischemic conditions [ISO]
- striated muscle contraction [ISO]
- vasculogenesis [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.
Mst1 (mammalian sterile 20-like kinase 1) is a ubiquitously expressed serine/threonine kinase and its activation in the heart causes cardiomyocyte apoptosis and dilated cardiomyopathy. Its myocardial substrates, however, remain unknown. In a yeast two-hybrid screen of a human heart cDNA library with a dominant-negative Mst1 (K59R) mutant used as bait, cTn [cardiac Tn (troponin)] I was identified as an Mst1-interacting ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID