BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IGF1R
CD221, IGFIR, IGFR, JTK13
insulin-like growth factor 1 receptor
GO Process (15)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- immune response [IMP]
- inactivation of MAPKK activity [IDA]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [IMP]
- phosphatidylinositol 3-kinase signaling [IC]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of JNK cascade [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID