BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KCNMA1
BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1, RP11-443A13.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- micturition [IDA]
- negative regulation of cell volume [IDA]
- positive regulation of apoptotic process [IMP]
- potassium ion transmembrane transport [IBA, IDA]
- potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- response to calcium ion [IDA]
- response to carbon monoxide [IDA, IMP]
- response to hypoxia [IDA]
- response to osmotic stress [IDA]
- smooth muscle contraction involved in micturition [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID