BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VAV2
VAV-2
vav 2 guanine nucleotide exchange factor
GO Process (15)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of GTPase activity [EXP, TAS]
- positive regulation of apoptotic process [TAS]
- regulation of blood coagulation [IMP]
- regulation of gene expression [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID