BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CACNA1H
CACNA1HB, Cav3.2, ECA6, EIG6
calcium channel, voltage-dependent, T type, alpha 1H subunit
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- aldosterone biosynthetic process [IMP]
- axon guidance [TAS]
- calcium ion import [IDA]
- cellular response to hormone stimulus [IEP]
- cellular response to potassium ion [IEP]
- cortisol biosynthetic process [IMP]
- membrane depolarization during action potential [IBA]
- muscle contraction [TAS]
- muscle organ development [NAS]
- myoblast fusion [TAS]
- positive regulation of acrosome reaction [IMP]
- regulation of heart contraction [TAS]
- regulation of membrane potential [IDA]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID