BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDCD6IP
AIP1, ALIX, DRIP4, HP95
programmed cell death 6 interacting protein
GO Process (7)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- regulation of extracellular vesicular exosome assembly [IMP]
- ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]
- viral budding via host ESCRT complex [IGI]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID