BAIT
HNRNPL
HNRPL, hnRNP-L, P/OKcl.14
heterogeneous nuclear ribonucleoprotein L
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SEMA4D
C9orf164, CD100, M-sema-G, SEMAJ, coll-4, XXyac-YM68G7.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
GO Process (22)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell adhesion [TAS]
- immune response [TAS]
- leukocyte aggregation [IMP]
- negative regulation of alkaline phosphatase activity [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- ossification involved in bone maturation [IMP]
- positive regulation of Rho GTPase activity [IMP, ISS]
- positive regulation of cell migration [IDA, ISS]
- positive regulation of collateral sprouting [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell projection organization [IMP]
- regulation of cell shape [IMP]
- regulation of dendrite morphogenesis [IMP]
- semaphorin-plexin signaling pathway [IDA, IMP]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.
Alternative RNA splicing plays an important role in cancer. To determine which factors involved in RNA processing are essential in prostate cancer, we performed a genome-wide CRISPR/Cas9 knockout screen to identify the genes that are required for prostate cancer growth. Functional annotation defined a set of essential spliceosome and RNA binding protein (RBP) genes, including most notably heterogeneous nuclear ribonucleoprotein ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 27, 2016; 114(26);E5207-E5215 [Pubmed: 28611215]
Throughput
- High Throughput
Curated By
- BioGRID