BAIT
PLCG1
PPLCA
phospholipase C, gamma 1
GO Process (19)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- calcium ion transport [IMP]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO, ISS]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [ISO]
- inositol trisphosphate biosynthetic process [IMP]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [IMP, ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [IMP]
- regulation of store-operated calcium channel activity [IMP]
- response to gravity [IEP]
- response to hydrogen peroxide [IEP]
- response to morphine [IEP]
- response to organonitrogen compound [IEP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GRB2
growth factor receptor bound protein 2
GO Process (15)
GO Function (14)
GO Component (14)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1.
Phospholipase C-gamma1 (PLC-gamma1) plays pivotal roles in cellular growth and proliferation. Upon the stimulation of growth factors and hormones, PLC-gamma1 is rapidly phosphorylated at three known sites; Tyr771, Tyr783 and Tyr1254 and its enzymatic activity is up-regulated. In this study, we demonstrate for the first time that Grb2, an adaptor protein, specifically interacts with tyrosine-phosphorylated PLC-gamma1 at Tyr783. The association ... [more]
Cell. Signal. Oct. 01, 2005; 17(10);1289-99 [Pubmed: 16038803]
Throughput
- Low Throughput
Curated By
- BioGRID