ITGB3
Gene Ontology Biological Process
- activation of protein kinase activity [IMP]
- angiogenesis involved in wound healing [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP]
- cell-substrate adhesion [IMP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [IDA, TAS]
- leukocyte migration [TAS]
- mesodermal cell differentiation [IEP]
- negative chemotaxis [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- platelet activation [IMP, TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein folding [IDA]
- regulation of bone resorption [TAS]
- smooth muscle cell migration [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- tube development [TAS]
- viral entry into host cell [IMP]
- wound healing [IC]
Gene Ontology Molecular Function- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
- cell adhesion molecule binding [IPI]
- extracellular matrix binding [IDA]
- fibronectin binding [IMP]
- identical protein binding [IPI]
- platelet-derived growth factor receptor binding [TAS]
- protease binding [IDA]
- protein binding [IPI]
- protein disulfide isomerase activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI, TAS]
Gene Ontology Cellular Component
- alphav-beta3 integrin-vitronectin complex [TAS]
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [TAS]
- integrin alphav-beta3 complex [IDA]
- integrin complex [IDA]
- lamellipodium membrane [IDA]
- melanosome [IDA]
- microvillus membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- platelet alpha granule membrane [TAS]
- receptor complex [IDA]
- ruffle membrane [IDA]
ITGAV
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- angiogenesis [IEP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [IDA]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP, NAS]
- cell-substrate adhesion [IMP]
- endodermal cell differentiation [IMP]
- entry of symbiont into host cell by promotion of host phagocytosis [NAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [TAS]
- negative chemotaxis [IMP]
- negative regulation of entry of bacterium into host cell [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic cell clearance [ISS]
- regulation of phagocytosis [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- viral entry into host cell [IMP, TAS]
Gene Ontology Molecular Function- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
- alphav-beta3 integrin-IGF-1-IGF1R complex [IDA]
- cell surface [IDA, ISS]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [NAS]
- integrin alphav-beta3 complex [IDA]
- integrin alphav-beta5 complex [IDA]
- integrin alphav-beta8 complex [IDA]
- integrin complex [IDA, NAS]
- lamellipodium membrane [IDA]
- membrane [ISS]
- microvillus membrane [IDA]
- phagocytic vesicle [TAS]
- plasma membrane [IDA, TAS]
- ruffle membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen.
Platelet retraction of a fibrin clot is mediated by the platelet fibrinogen receptor, alpha(IIb)beta(3). In certain forms of the inherited platelet disorder, Glanzmann thrombasthenia (GT), mutant alpha(IIb)beta(3) may interact normally with fibrin yet fail to support fibrinogen-dependent aggregation. We describe a patient (LD) with such a form of GT. Platelets from LD supported normal clot retraction but failed to bind ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITGB3 ITGAV | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - | |
| ITGB3 ITGAV | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2297625 |
Curated By
- BioGRID