BAIT
LNX1
LNX, MPDZ, PDZRN2, UNQ574/PRO1136
ligand of numb-protein X 1, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
PLEK
P47
pleckstrin
GO Process (25)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cell projection organization [IDA]
- cortical actin cytoskeleton organization [IDA]
- hematopoietic progenitor cell differentiation [IEP]
- integrin-mediated signaling pathway [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of calcium-mediated signaling [NAS]
- negative regulation of inositol phosphate biosynthetic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP, ISS]
- platelet degranulation [IEP, TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of inositol-polyphosphate 5-phosphatase activity [IDA]
- positive regulation of integrin activation [ISS]
- positive regulation of platelet activation [ISS]
- protein kinase C signaling [ISS]
- protein secretion by platelet [ISS]
- regulation of cell diameter [IDA]
- ruffle organization [IDA]
- thrombin receptor signaling pathway [IDA]
- vesicle docking involved in exocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.
Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the physiological relevance of these interactions in vivo remain unclear. To gain functional insights into the LNX family, we ... [more]
PLoS ONE Nov. 10, 2017; 12(11);e0187352 [Pubmed: 29121065]
Throughput
- High Throughput
Curated By
- BioGRID