BAIT
LNX1
LNX, MPDZ, PDZRN2, UNQ574/PRO1136
ligand of numb-protein X 1, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
TMED10
P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23
transmembrane emp24-like trafficking protein 10 (yeast)
GO Process (10)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- COPI coating of Golgi vesicle [TAS]
- COPI-coated vesicle budding [IDA]
- COPII vesicle coating [TAS]
- ER to Golgi vesicle-mediated transport [TAS]
- cargo loading into vesicle [TAS]
- intracellular protein transport [IDA]
- regulated secretory pathway [ISS]
- regulation of beta-amyloid formation [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISS]
- vesicle targeting, to, from or within Golgi [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COPI-coated vesicle [ISS]
- Golgi apparatus [IDA]
- Golgi membrane [IDA, TAS]
- cis-Golgi network [ISS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA]
- extracellular vesicular exosome [IDA]
- gamma-secretase complex [IDA]
- integral component of membrane [ISS]
- plasma membrane [ISS]
- secretory granule membrane [ISS]
- trans-Golgi network transport vesicle [ISS]
- zymogen granule membrane [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.
Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the physiological relevance of these interactions in vivo remain unclear. To gain functional insights into the LNX family, we ... [more]
PLoS ONE Nov. 10, 2017; 12(11);e0187352 [Pubmed: 29121065]
Throughput
- High Throughput
Curated By
- BioGRID