BAIT

IFNAR1

AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
interferon (alpha, beta and omega) receptor 1
Homo sapiens
PREY

UBA1

A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X, CTD-2522E6.1
ubiquitin-like modifier activating enzyme 1
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

Zheng H, Gupta V, Patterson-Fortin J, Bhattacharya S, Katlinski K, Wu J, Varghese B, Carbone CJ, Aressy B, Fuchs SY, Greenberg RA

Lysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events. The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that are specific for K63-Ub hydrolysis. RAP80 targets the five-member nuclear BRCC36 complex to K63-Ub chains at DNA double-strand breaks. The alternative four-member BRCC36 containing complex (BRISC) lacks a known targeting moiety. Here, we ... [more]

Cell Rep Oct. 17, 2013; 5(1);180-93 [Pubmed: 24075985]

Throughput

  • High Throughput

Curated By

  • BioGRID