BAIT
ID1
ID, bHLHb24
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
GO Process (7)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [TAS]
- blood vessel endothelial cell migration [TAS]
- blood vessel morphogenesis [TAS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription by transcription factor localization [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IC]
Homo sapiens
PREY
CASK
CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, RP11-540L11.1
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (7)
GO Function (2)
GO Component (11)
Gene Ontology Biological Process
- cell adhesion [TAS]
- extracellular matrix organization [TAS]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cellular response to growth factor stimulus [IMP]
- negative regulation of keratinocyte proliferation [IMP]
- negative regulation of wound healing [IMP]
- nucleotide phosphorylation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
CASK inhibits ECV304 cell growth and interacts with Id1.
Calcium/calmodulin-dependent serine protein kinase (CASK) is generally known as a scaffold protein. Here we show that overexpression of CASK resulted in a reduced rate of cell growth, while inhibition of expression of endogenous CASK via RNA-mediated interference resulted in an increased rate of cell growth in ECV304 cells. To explore the molecular mechanism, we identified a novel CASK-interacting protein, inhibitor ... [more]
Biochem. Biophys. Res. Commun. Mar. 11, 2005; 328(2);517-21 [Pubmed: 15694377]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID