BAIT
PTPN2
AI325124, Ptpt, TC-PTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (31)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemotaxis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of interleukin-2-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-4-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-6-mediated signaling pathway [IMP, ISO]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage colony-stimulating factor signaling pathway [IMP]
- negative regulation of macrophage differentiation [IMP]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of positive thymic T cell selection [IMP]
- negative regulation of prolactin signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- negative regulation of type I interferon-mediated signaling pathway [IMP, ISO]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of gluconeogenesis [IMP]
- protein dephosphorylation [IMP]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
JAK1
AA960307, BAP004, C130039L05Rik, RP23-336G7.2
Janus kinase 1
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cytokine-mediated signaling pathway [IDA]
- enzyme linked receptor protein signaling pathway [IDA]
- innate immune response [IBA]
- interleukin-2-mediated signaling pathway [ISO]
- intracellular signal transduction [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- protein autophosphorylation [ISO]
- regulation of cell proliferation [IBA]
- response to antibiotic [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening approach using CRISPR-Cas9 genome editing in transplantable tumours in mice treated with immunotherapy to discover previously undescribed immunotherapy targets. We tested 2,368 genes expressed by melanoma cells to identify ... [more]
Nature Dec. 27, 2016; 547(7664);413-418 [Pubmed: 28723893]
Throughput
- Low Throughput
Ontology Terms
- phenotype: altered tumor susceptibility (MP:0002166)
Additional Notes
- the mechanism by which Ptpn2 deficiency sensitizes tumour cells to immunotherapy is dependent on the sensing of IFNgamma and is abrogated by deletion of Stat1, Jak1 or Ifngr1
Curated By
- BioGRID