BAIT

SYT1

P65, SVP65, SYT
synaptotagmin I
Autism spectrum disorder (ASD) Project
Homo sapiens
PREY

SV2C

synaptic vesicle glycoprotein 2C
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

SV2B regulates synaptotagmin 1 by direct interaction.

Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R

SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor (SV2C) isoform. SV2A and SV2B have been shown to be involved in the regulation of synaptic vesicle exocytosis. Previous studies found that SV2A, but not SV2B, can interact with the cytoplasmic domain of synaptotagmin 1, a Ca2+ sensor for synaptic vesicle exocytosis. To ... [more]

J. Biol. Chem. Dec. 10, 2004; 279(50);52124-31 [Pubmed: 15466855]

Throughput

  • Low Throughput

Curated By

  • BioGRID