BAIT
SNCG
BCSG1, SR
synuclein, gamma (breast cancer-specific protein 1)
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
DYNLL1
DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1
dynein, light chain, LC8-type 1
GO Process (11)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Mapping protein-protein interactions is an invaluable tool for understanding protein function. Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. The study maps protein interactions for 338 bait proteins that were selected based on known or suspected disease and functional associations. Large-scale immunoprecipitation of Flag-tagged versions of these proteins followed by ... [more]
Mol. Syst. Biol. Mar. 14, 2007; 3(0);89 [Pubmed: 17353931]
Quantitative Score
- 0.368 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007)
Additional Notes
- Exogenous expression of bait
Curated By
- BioGRID