BAIT

APC2

APCL
adenomatosis polyposis coli 2
Homo sapiens
PREY

ACTA1

ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, RP5-1068B5.2
actin, alpha 1, skeletal muscle
Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Human APC2 localization and allelic imbalance.

Jarrett CR, Blancato J, Cao T, Bressette DS, Cepeda M, Young PE, King CR, Byers SW

A second adenomatous polyposis coli (APC)-like gene, APC2/APCL, was recently described and localized to chromosome 19. We have fine mapped APC2 to a small region of chromosome 19p13.3 containing markers D19S883 and WI-19632, a region commonly lost in a variety of cancers, particularly ovarian cancer. Interphase fluorescence in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ... [more]

Cancer Res. Nov. 01, 2001; 61(21);7978-84 [Pubmed: 11691822]

Throughput

  • Low Throughput

Additional Notes

  • APC2 remained associated with actin filaments after treatment with the actin-disrupting agent, cytochalasin D

Curated By

  • BioGRID