BAIT
ZEB1
3110032K11Rik, AREB6, BZP, MEB1, Nil2, TCF-8, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a, Zfx1ha, [delta]EF1
zinc finger E-box binding homeobox 1
GO Process (20)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- cartilage development [IMP]
- cellular response to amino acid stimulus [IDA]
- central nervous system development [IGI]
- cochlea morphogenesis [IMP]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic morphogenesis [IGI]
- embryonic skeletal system morphogenesis [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- organ development [IMP]
- pattern specification process [IMP]
- positive regulation of neuron differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- regulation of T cell differentiation in thymus [IMP]
- regulation of mesenchymal cell proliferation [IMP]
- regulation of smooth muscle cell differentiation [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IGI]
- semicircular canal morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTBP1
BARS, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115, D5H4S115E
C-terminal binding protein 1
GO Process (10)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- Golgi organization [ISO]
- chromatin organization involved in regulation of transcription [ISO]
- negative regulation of histone H4 acetylation [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone deacetylation [ISO]
- regulation of cell cycle [ISO]
- transcription from RNA polymerase II promoter [ISO]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1.
deltaEF1, a representative of the zinc finger-homeodomain protein family, is a transcriptional repressor which binds E2-box (CACCTG) and related sequences and counteracts the activators through transrepression mechanisms. It has been shown that the N-proximal region of the protein is involved in the transrepression. Here we demonstrate that deltaEF1 has a second mechanism of transrepression recruiting CtBP1 or CtBP2 as its ... [more]
Mol. Cell. Biol. Dec. 01, 1999; 19(12);8581-90 [Pubmed: 10567582]
Throughput
- Low Throughput
Additional Notes
- Bind to deltaEF1 in a manner dependent on the PLDLSL sequence located in the short medial (MS) portion of deltaEF1
Curated By
- BioGRID