BRCA1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [TAS]
- DNA repair [TAS]
- G2 DNA damage checkpoint [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to tumor necrosis factor [IMP]
- chordate embryonic development [IBA]
- chromosome segregation [IMP]
- dosage compensation by inactivation of X chromosome [IBA]
- double-strand break repair [IMP, TAS]
- double-strand break repair via homologous recombination [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of centriole replication [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fatty acid biosynthetic process [IMP]
- negative regulation of histone H3-K9 methylation [IDA]
- negative regulation of histone acetylation [IBA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K9 acetylation [IDA]
- positive regulation of histone H4-K16 acetylation [IDA]
- positive regulation of histone H4-K20 methylation [IDA]
- positive regulation of histone acetylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [NAS, TAS]
- positive regulation vascular endothelial growth factor production [IMP]
- postreplication repair [IDA]
- protein K6-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell proliferation [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase III promoter [TAS]
- response to estrogen [IDA]
- response to ionizing radiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MSH3
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- DNA repair [IDA]
- maintenance of DNA repeat elements [IMP]
- meiotic mismatch repair [IBA]
- mismatch repair [IMP]
- negative regulation of DNA recombination [IDA]
- positive regulation of helicase activity [IDA]
- reciprocal meiotic recombination [IBA]
- somatic recombination of immunoglobulin gene segments [IBA]
Gene Ontology Molecular Function- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- enzyme binding [IPI]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IBA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- single guanine insertion binding [IDA]
- single-stranded DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- enzyme binding [IPI]
- guanine/thymine mispair binding [IDA]
- heteroduplex DNA loop binding [IBA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- single guanine insertion binding [IDA]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
Protein phosphorylation by protein kinases may generate docking sites for other proteins. It thus allows the assembly of signaling complexes in response to kinase activation. Several protein domains that bind phosphoserine or phosphothreonine residues have been identified, including the 14-3-3, PIN1, FHA, KIX, WD-40 domain, and polo box (Yaffe, M. B., and Elia, A. E. (2001) Curr. Opin. Cell Biol. ... [more]
Throughput
- Low Throughput
Additional Notes
- BRCA1 BRCT domains preferred a [YE]E-[TV]-pS-[YFH]-[VTYF]-[FY] motif with weak selection at the NH2 terminus;predicted partners
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRCA1 MSH3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID