BAIT
ARHGDIA
GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cellular component movement [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell adhesion [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- semaphorin-plexin signaling pathway [ISS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CASP10
ALPS2, FLICE2, MCH4
caspase 10, apoptosis-related cysteine peptidase
GO Process (4)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
While investigating the mechanism of action of the novel antitumor drug Aplidin, we have discovered a potent and novel cell-killing mechanism that involves the formation of Fas/CD95-driven scaffolds in membrane raft clusters housing death receptors and apoptosis-related molecules. Fas, tumor necrosis factor-receptor 1, and tumor necrosis factor-related apoptosis-inducing ligand receptor 2/death receptor 5 were clustered into lipid rafts in leukemic ... [more]
J. Biol. Chem. Mar. 25, 2005; 280(12);11641-7 [Pubmed: 15659383]
Throughput
- Low Throughput
Additional Notes
- Fas, tumor necrosis factor-receptor 1, and tumor necrosis factor-related apoptosis-inducing ligand receptor 2/death receptor 5 were clustered into lipid rafts in leukemic Jurkat cells following Aplidin treatment;Fas ligand (FasL) as well as downstream sig
Curated By
- BioGRID