LYN
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- Fc receptor mediated inhibitory signaling pathway [ISS]
- Fc receptor mediated stimulatory signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [IMP]
- central nervous system development [IBA]
- dendritic cell differentiation [IBA, ISS]
- erythrocyte differentiation [ISS]
- immune response-regulating cell surface receptor signaling pathway [ISS, TAS]
- inflammatory response [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- lipopolysaccharide-mediated signaling pathway [ISS]
- negative regulation of B cell proliferation [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of immune response [TAS]
- negative regulation of intracellular signal transduction [ISS]
- negative regulation of mast cell proliferation [IBA, ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [IBA, ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cellular component movement [IDA]
- positive regulation of dendritic cell apoptotic process [IBA, ISS]
- positive regulation of mast cell proliferation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [IDA]
- positive regulation of tyrosine phosphorylation of STAT protein [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of B cell apoptotic process [IBA]
- regulation of B cell receptor signaling pathway [IBA, ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of cytokine production [ISS]
- regulation of erythrocyte differentiation [ISS]
- regulation of mast cell activation [ISS]
- regulation of mast cell degranulation [IBA, ISS]
- regulation of monocyte chemotaxis [IMP]
- regulation of platelet aggregation [IBA, ISS]
- regulation of protein phosphorylation [TAS]
- response to hormone [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- tolerance induction to self antigen [IBA, ISS, TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MUC1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]
- O-glycan processing [TAS]
- cellular protein metabolic process [TAS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- negative regulation of transcription by competitive promoter binding [IDA]
- positive regulation of histone H4 acetylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [IDA]
- post-translational protein modification [TAS]
- regulation of transcription from RNA polymerase II promoter in response to stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7.
The human DF3/MUC1 transmembrane protein is aberrantly expressed in multiple myeloma cells and other B cell malignancies. The regulation of MUC1 in B cells and its potential function as a signaling molecule are unknown. The present results demonstrate that interleukin-7 (IL-7) stimulates MUC1 expression in multiple myeloma cells. The results also demonstrate the IL-7 induces binding of MUC1 to the ... [more]
Throughput
- Low Throughput
Additional Notes
- IL-7 induces binding of MUC1 to the Lyn tyrosine kinase. The MUC1 C-terminal subunit binds directly to Lyn through interactions with the Lyn SH3 and SH2 domains. Activation of Lyn in response to IL-7 stimulation results in increased tyrosine phosphorylati
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LYN MUC1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 244420 |
Curated By
- BioGRID