BAIT
MDC1
NFBD1, DAAP-285E11.7
mediator of DNA-damage checkpoint 1
GO Process (4)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HDAC8
CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS, CDA07
histone deacetylase 8
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
Protein phosphorylation by protein kinases may generate docking sites for other proteins. It thus allows the assembly of signaling complexes in response to kinase activation. Several protein domains that bind phosphoserine or phosphothreonine residues have been identified, including the 14-3-3, PIN1, FHA, KIX, WD-40 domain, and polo box (Yaffe, M. B., and Elia, A. E. (2001) Curr. Opin. Cell Biol. ... [more]
J. Biol. Chem. Dec. 26, 2003; 278(52);52914-8 [Pubmed: 14578343]
Throughput
- Low Throughput
Additional Notes
- MDC1 BRCT domains bind phosphopeptides with the motif pS-hydrophobic-[EVDI]-[YF];predicted partners
Curated By
- BioGRID