BAIT

ZUFSP

C6orf113, dJ412I7.3, RP3-412I7.3
zinc finger with UFM1-specific peptidase domain
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

FKBP15

FKBP133, KIAA0674, PPP1R76
FK506 binding protein 15, 133kDa
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

Kwasna D, Abdul Rehman SA, Natarajan J, Matthews S, Madden R, De Cesare V, Weidlich S, Virdee S, Ahel I, Gibbs-Seymour I, Kulathu Y

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and catalysis. Our analyses reveal that ZUFSP is a novel DUB with no homology to any known DUBs, leading us to classify ZUFSP as the ... [more]

Mol. Cell Apr. 05, 2018; 70(1);150-164.e6 [Pubmed: 29576527]

Throughput

  • High Throughput

Curated By

  • BioGRID