BAIT

ZUFSP

C6orf113, dJ412I7.3, RP3-412I7.3

zinc finger with UFM1-specific peptidase domain

UPS Project

GO Process (0)

GO Function (0)

GO Component (0)

CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

DTNB

dystrobrevin, beta

GO Process (0)

GO Function (0)

GO Component (0)

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

Kwasna D, Abdul Rehman SA, Natarajan J, Matthews S, Madden R, De Cesare V, Weidlich S, Virdee S, Ahel I, Gibbs-Seymour I, Kulathu Y

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and catalysis. Our analyses reveal that ZUFSP is a novel DUB with no homology to any known DUBs, leading us to classify ZUFSP as the ... [more]

Mol. Cell Apr. 05, 2018; 70(1);150-164.e6 [Pubmed: 29576527]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary