ARC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DNM2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- GTP catabolic process [TAS]
- cellular response to X-ray [IEP]
- cilium morphogenesis [IMP]
- endocytosis [TAS]
- macropinocytosis [IMP]
- negative regulation of membrane tubulation [ISO]
- neuron projection morphogenesis [IMP]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, IMP]
- regulation of axon extension [IMP]
- response to light stimulus [IEP]
- spermatogenesis [IEP]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell junction [IDA]
- centrosome [IDA]
- clathrin-coated endocytic vesicle [IDA]
- coated pit [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- lamellipodium [IDA]
- microtubule [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- photoreceptor inner segment [ISO]
- plasma membrane [IDA, TAS]
- postsynaptic membrane [ISO, ISS]
- protein complex [IDA]
- ruffle membrane [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo.
Activity-regulatedcytoskeleton-associated protein (Arc) protein is implicated as a master regulator of long-term forms of synaptic plasticity and memory formation, but the mechanisms controlling Arc protein function are little known. Post-translation modification by small ubiquitin-like modifier (SUMO) proteins has emerged as a major mechanism for regulating protein-protein interactions and function. We first show in cell lines that ectopically expressed Arc undergoes ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DNM2 ARC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID