BAIT
FGF2
Fgf-2, Fgfb, bFGF, DN-452A22.6
fibroblast growth factor 2
GO Process (51)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- angiogenesis [IDA, IGI]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cardiac muscle cell proliferation [TAS]
- cell migration involved in sprouting angiogenesis [ISO]
- chondroblast differentiation [ISO]
- corticotropin hormone secreting cell differentiation [IDA]
- embryo development ending in birth or egg hatching [ISO]
- fibroblast growth factor receptor signaling pathway [IGI, ISO]
- glial cell differentiation [IMP]
- hyaluronan catabolic process [ISO]
- inositol phosphate biosynthetic process [ISO]
- lung development [IDA, IGI]
- mammary gland epithelial cell differentiation [IDA]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of fibroblast migration [ISO]
- negative regulation of wound healing [ISO]
- organ induction [IDA]
- phosphatidylinositol biosynthetic process [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of angiogenesis [IDA, IGI, ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell differentiation [IDA]
- positive regulation of cell fate specification [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO, TAS]
- regulation of cell cycle [IDA]
- regulation of retinal cell programmed cell death [IDA]
- release of sequestered calcium ion into cytosol [ISO]
- response to axon injury [IMP]
- stem cell development [IMP]
- substantia nigra development [IMP]
- thyroid-stimulating hormone-secreting cell differentiation [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
FGFR1
AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr
fibroblast growth factor receptor 1
GO Process (41)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- angiogenesis [IGI]
- auditory receptor cell development [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- cell maturation [IMP]
- chondrocyte differentiation [IGI]
- embryonic limb morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- generation of neurons [IMP]
- in utero embryonic development [IGI]
- inner ear morphogenesis [IMP]
- lung development [IGI, IMP]
- lung-associated mesenchyme development [IGI]
- mesenchymal cell differentiation [IGI]
- midbrain development [IGI, IMP]
- middle ear morphogenesis [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- orbitofrontal cortex development [IMP]
- organ induction [IMP]
- outer ear morphogenesis [IMP]
- paraxial mesoderm development [IGI]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [IGI]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of mesenchymal cell proliferation [IGI, IMP]
- positive regulation of neuron projection development [IGI]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
- regulation of cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- regulation of gene expression [IMP]
- regulation of lateral mesodermal cell fate specification [IGI]
- salivary gland morphogenesis [IMP]
- sensory perception of sound [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength.
In the mature nervous system, changes in synaptic strength correlate with changes in neuronal structure. Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the myelin inhibitors Nogo-A, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), and is important for growth cone collapse in response to acutely presented inhibitors ... [more]
J. Neurosci. Mar. 12, 2008; 28(11);2753-65 [Pubmed: 18337405]
Throughput
- Low Throughput
Curated By
- BioGRID