BLVRA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCB
Gene Ontology Biological Process
- B cell activation [ISS]
- B cell receptor signaling pathway [ISS]
- blood coagulation [TAS]
- histone H3-T6 phosphorylation [IDA]
- lipoprotein transport [TAS]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- platelet activation [TAS]
- positive regulation of B cell receptor signaling pathway [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- protein phosphorylation [TAS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- signal transduction [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.
Human biliverdin reductase (hBVR) is a dual function enzyme: a catalyst for bilirubin formation and a S/T/Y kinase that shares activators with protein kinase C (PKC) -zeta, including cytokines, insulin, and reactive oxygen species (ROS). Presently, we show that hBVR increases PKC-zeta autophosphorylation, stimulation by TNF-alpha, as well as cytokine stimulation of NF-kappaB DNA binding and promoter activity. S149 in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BLVRA PRKCB | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID